Rheumatoid Arthritis

The synovial membrane, composed of a mixed population of cells with phenotypic characteristics of fibroblasts and macrophages, is the site where the joint inflammatory process begins. This phenomenon occurs after the infiltration of the synovium found in the joints by hyperactivated T lymphocytes and B lymphocytes, endothelial cells, and activated macrophages, all these activated cells lead to a very marked hyperplasia (growth) of the synovium and the destruction of the bone located in the contact areas in the joints that result in bone destruction, with the manifestations of inflammation, swelling, pain and deformity.

Regulatory T Cells in Arthritis Treatment

Conventional treatments for the treatment of Rheumatoid Arthritis include steroids, immune response modifiers, chemotherapeutics, the mechanism of action in general is the destruction of hyperactivated lymphocytes, which causes the appearance of recurrent infections, and damage to organs and fabrics over time.

The objective of cellular immunotherapy with the patient’s own regulatory T lymphocytes is to increase their number and activate them, so that in this way they can regulate the hyperactivated lymphocyte, but not destroy it.